Intracellular lactate- and pyruvate-interconversion rates are increased in muscle tissue of non-insulin-dependent diabetic individuals.

@article{Avogaro1996IntracellularLA,
  title={Intracellular lactate- and pyruvate-interconversion rates are increased in muscle tissue of non-insulin-dependent diabetic individuals.},
  author={Angelo Avogaro and Gianna Toffolo and Marta Miola and A Valerio and Antonio Tiengo and Claudio Cobelli and Stefano Del Prato},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={98 1},
  pages={108-15}
}
The contribution of muscle tissues of non-insulin-dependent diabetes mellitus (NIDDM) patients to blood lactate appearance remains undefined. To gain insight on intracellular pyruvate/lactate metabolism, the postabsorptive forearm metabolism of glucose, lactate, FFA, and ketone bodies (KB) was assessed in seven obese non-insulin-dependent diabetic patients (BMI = 28.0 +/- 0.5 kg/m2) and seven control individuals (BMI = 24.8 +/- 0.5 kg/m2) by using arteriovenous balance across forearm tissues… CONTINUE READING

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