Intracellular ionic strength regulates the volume sensitivity of a swelling-activated anion channel.

@article{Cannon1998IntracellularIS,
  title={Intracellular ionic strength regulates the volume sensitivity of a swelling-activated anion channel.},
  author={Carolyn L. Cannon and Srisaila Basavappa and Kevin Strange},
  journal={The American journal of physiology},
  year={1998},
  volume={275 2 Pt 1},
  pages={C416-22}
}
Cell swelling activates an outwardly rectifying anion channel termed VSOAC (volume-sensitive organic osmolyte/anion channel). Regulation of VSOAC by intracellular electrolytes was characterized in Chinese hamster ovary cells by whole cell patch clamp. Elevation of intracellular CsCl concentration from 40 to 180 mM resulted in a concentration-dependent… CONTINUE READING