Intracellular interaction of interleukin-15 with its receptor alpha during production leads to mutual stabilization and increased bioactivity.

@article{Bergamaschi2008IntracellularIO,
  title={Intracellular interaction of interleukin-15 with its receptor alpha during production leads to mutual stabilization and increased bioactivity.},
  author={Cristina Bergamaschi and Margherita Rosati and Rashmi Jalah and Antonio Valent{\'i}n and Viraj Kulkarni and Candido Alicea and Gen-mu Zhang and Vainav Patel and Barbara K Felber and George N Pavlakis},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 7},
  pages={4189-99}
}
We show that co-expression of interleukin 15 (IL-15) and IL-15 receptor alpha (IL-15Ralpha) in the same cell allows for the intracellular interaction of the two proteins early after translation, resulting in increased stability and secretion of both molecules as a complex. In the absence of co-expressed IL-15Ralpha, a large portion of the produced IL-15 is rapidly degraded immediately after synthesis. Co-injection into mice of IL-15 and IL-15Ralpha expression plasmids led to significantly… CONTINUE READING