Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1.

@article{Smiley1991IntracellularHI,
  title={Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1.},
  author={S T Smiley and Martin Reers and C Mottola-Hartshorn and M Lin and A B Chen and T. W. Smith and Glenn D. Steele and Li Ban Chen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88},
  pages={3671 - 3675}
}
  • S. Smiley, M. Reers, +5 authors L. B. Chen
  • Published 1 May 1991
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
By using a potential-dependent J-aggregate-forming delocalized lipophilic cation, 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine++ + iodide (JC-1), we find that membrane potentials across mitochondria in a living cell can be heterogeneous. Remarkably, even within a long contiguous mitochondrion, regional heterogeneity in membrane potentials appears to be possible. 
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