Intracellular growth of Legionella pneumophila gives rise to a differentiated form dissimilar to stationary-phase forms.

@article{Garduo2002IntracellularGO,
  title={Intracellular growth of Legionella pneumophila gives rise to a differentiated form dissimilar to stationary-phase forms.},
  author={Rafael A. Gardu{\~n}o and Elizabeth R Garduno and Margot F Hiltz and Paul S. Hoffman},
  journal={Infection and immunity},
  year={2002},
  volume={70 11},
  pages={6273-83}
}
When Legionella pneumophila grows in HeLa cells, it alternates between a replicative form and a morphologically distinct "cyst-like" form termed MIF (mature intracellular form). MIFs are also formed in natural amoebic hosts and to a lesser extent in macrophages, but they do not develop in vitro. Since MIFs accumulate at the end of each growth cycle, we investigated the possibility that they are in vivo equivalents of stationary-phase (SP) bacteria, which are enriched for virulence traits. By… CONTINUE READING
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