Intracellular glutathione and bronchoalveolar cells in fibrosing alveolitis: effects of N-acetylcysteine

@article{Behr2002IntracellularGA,
  title={Intracellular glutathione and bronchoalveolar cells in fibrosing alveolitis: effects of N-acetylcysteine},
  author={J. Behr and B. Degenkolb and F. Krombach and C. Vogelmeier},
  journal={European Respiratory Journal},
  year={2002},
  volume={19},
  pages={906 - 911}
}
  • J. Behr, B. Degenkolb, +1 author C. Vogelmeier
  • Published 2002
  • Medicine
  • European Respiratory Journal
  • Extracellular glutathione deficiency and exaggerated oxidative stress may contribute to the pathogenesis of fibrosing alveolitis (FA). High-dose N-acetylcysteine (NAC) supplementation partially reverses extracellular glutathione depletion and oxidative damage, but effects on intracellular glutathione are unknown. Intracellular total glutathione (GSHt) and activation of bronchoalveolar lavage cells (BAC) obtained from 18 FA patients (9 males, aged 52±2 yrs), before and after 12 weeks of oral NAC… CONTINUE READING

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