Intracellular generation of free radicals and modifications of detoxifying enzymes in cultured neurons from the developing rat forebrain in response to transient hypoxia.

@article{Livre2001IntracellularGO,
  title={Intracellular generation of free radicals and modifications of detoxifying enzymes in cultured neurons from the developing rat forebrain in response to transient hypoxia.},
  author={Val{\'e}rie Li{\`e}vre and Philippe Becuwe and Arnaud Bianchi and Carine Bossenmeyer-Pouri{\'e} and Violette Koziel and Patricia Franck and Maryse Nicolas and Michel Dauça and Paul Vert and Jean Luc Daval},
  journal={Neuroscience},
  year={2001},
  volume={105 2},
  pages={287-97}
}
To address the influence of oxidative stress and defense capacities in the effects of transient hypoxia in the immature brain, the time course of reactive oxygen species generation was monitored by flow cytometry using dihydrorhodamine 123 and 2',7'-dichlorofluorescein-diacetate in cultured neurons issued from the fetal rat forebrain and subjected to hypoxia/reoxygenation (6 h/96 h). Parallel transcriptional and activity changes of superoxide dismutases, glutathione peroxidase and catalase were… CONTINUE READING
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