Intracellular gene transfer: reduced hydrophobicity facilitates gene transfer for subunit 2 of cytochrome c oxidase.

@article{Daley2002IntracellularGT,
  title={Intracellular gene transfer: reduced hydrophobicity facilitates gene transfer for subunit 2 of cytochrome c oxidase.},
  author={Daniel O Daley and Rachel Clifton and James Whelan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 16},
  pages={10510-5}
}
Subunit 2 of cytochrome c oxidase (Cox2) in legumes offers a rare opportunity to investigate factors necessary for successful gene transfer of a hydrophobic protein that is usually mitochondrial-encoded. We found that changes in local hydrophobicity were necessary to allow import of this nuclear-encoded protein into mitochondria. All legume species containing both a mitochondrial and nuclear encoded Cox2 displayed a similar pattern, with a large decrease in hydrophobicity evident in the first… CONTINUE READING

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