Intracellular functions of N-linked glycans.

@article{Helenius2001IntracellularFO,
  title={Intracellular functions of N-linked glycans.},
  author={Ari Helenius and Markus Aebi},
  journal={Science},
  year={2001},
  volume={291 5512},
  pages={
          2364-9
        }
}
N-linked oligosaccharides arise when blocks of 14 sugars are added cotranslationally to newly synthesized polypeptides in the endoplasmic reticulum (ER). These glycans are then subjected to extensive modification as the glycoproteins mature and move through the ER via the Golgi complex to their final destinations inside and outside the cell. In the ER and in the early secretory pathway, where the repertoire of oligosaccharide structures is still rather small, the glycans play a pivotal role in… 

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