Intracellular functions of N-linked glycans.

@article{Helenius2001IntracellularFO,
  title={Intracellular functions of N-linked glycans.},
  author={Ari Helenius and Markus Aebi},
  journal={Science},
  year={2001},
  volume={291 5512},
  pages={
          2364-9
        }
}
N-linked oligosaccharides arise when blocks of 14 sugars are added cotranslationally to newly synthesized polypeptides in the endoplasmic reticulum (ER). These glycans are then subjected to extensive modification as the glycoproteins mature and move through the ER via the Golgi complex to their final destinations inside and outside the cell. In the ER and in the early secretory pathway, where the repertoire of oligosaccharide structures is still rather small, the glycans play a pivotal role in… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 866 CITATIONS, ESTIMATED 62% COVERAGE

Bioprocess Engineering Framework to Control Protein N-linked Glycosylation

VIEW 12 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Site-specific N-glycosylation of chicken serum IgG.

VIEW 8 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

A Complex of Htm1 and the Oxidoreductase Pdi1 Accelerates Degradation of Misfolded Glycoproteins*

VIEW 5 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Disruption of N-linked glycosylation promotes proteasomal degradation of the human ATP-binding cassette transporter ABCA3.

VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2001
2020

CITATION STATISTICS

  • 56 Highly Influenced Citations

  • Averaged 42 Citations per year from 2017 through 2019