Intracellular free Ca2+, Na+, and H+ concentrations in the isolated perfused rat heart during the Ca2+ paradox.

@article{Diederichs1994IntracellularFC,
  title={Intracellular free Ca2+, Na+, and H+ concentrations in the isolated perfused rat heart during the Ca2+ paradox.},
  author={F Diederichs},
  journal={Cell calcium},
  year={1994},
  volume={15 4},
  pages={297-304}
}
Enzyme release from the normothermic perfused rat heart was determined to evaluate myocardial cell damage during the perfusion sequence of the Ca2+ Ca2+ paradox. In addition sarcosolic free Ca2+ and monovalent cation concentrations were measured using ion-selective microelectrodes (ISMEs). A reduction of the extracellular Ca2+ concentration, [Ca2+]e, from 1.0 mmol/l to 0.3 or 0.1 mmol/l, respectively, during the re-perfusion period markedly decreased the rate of enzyme release. Slow Ca2… CONTINUE READING