Intracellular evolution of mitochondrial DNA (mtDNA) and the tragedy of the cytoplasmic commons.

@article{Haig2016IntracellularEO,
  title={Intracellular evolution of mitochondrial DNA (mtDNA) and the tragedy of the cytoplasmic commons.},
  author={David Haig},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2016},
  volume={38 6},
  pages={549-55}
}
Mitochondria exist in large numbers per cell. Therefore, the strength of natural selection on individual mtDNAs for their contribution to cellular fitness is weak whereas the strength of selection in favor of mtDNAs that increase their own replication without regard for cellular functions is strong. This problem has been solved for most mitochondrial genes by their transfer to the nucleus but a few critical genes remain encoded by mtDNA. Organisms manage the evolution of mtDNA to prevent… CONTINUE READING

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