Intracellular dynamics of sst5 receptors in transfected COS-7 cells: maintenance of cell surface receptors during ligand-induced endocytosis.

@article{Stroh2000IntracellularDO,
  title={Intracellular dynamics of sst5 receptors in transfected COS-7 cells: maintenance of cell surface receptors during ligand-induced endocytosis.},
  author={Thomas Stroh and Alexander C Jackson and Philippe Sarret and Claude Dal Farra and J. P. Vincent and Hans J{\"u}rgen Kreienkamp and James Mazella and Alain Beaudet},
  journal={Endocrinology},
  year={2000},
  volume={141 1},
  pages={354-65}
}
Internalization of G protein-coupled receptors is crucial for resensitization of phosphorylation-desensitized receptors, but also for their long term desensitization through sequestration. To elucidate the mechanisms regulating cell surface availability of the somatostatin (SRIF) receptor subtype sst5, we characterized its internalization properties in transfected COS-7 cells using biochemical, confocal microscopic, and electron microscopic techniques. Our results demonstrated rapid and… CONTINUE READING

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Differential intra- cellular trafficking of neurotensin and of its receptor in cos-7 transfected cells

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