Intracellular dynamics of polydnavirus innexin homologues

@article{Hasegawa2020IntracellularDO,
  title={Intracellular dynamics of polydnavirus innexin homologues},
  author={Daniel K. Hasegawa and P. Zhang and Matthew W Turnbull},
  journal={Insect Molecular Biology},
  year={2020},
  volume={29}
}
Polydnaviruses associated with ichneumonid parasitoid wasps (Ichnoviruses) encode large numbers of genes, often in multigene families. The Ichnovirus Vinnexin gene family, which is expressed in parasitized lepidopteran larvae, encodes homologues of Innexins, the structural components of insect gap junctions. Here, we have examined intracellular behaviours of the Campoletis sonorensis Ichnovirus (CsIV) Vinnexins, alone and in combination with a host Innexin orthologue, Innexin2 (Inx2). QRT‐PCR… 
Polydnavirus Innexins Disrupt Host Cellular Encapsulation and Larval Maturation
TLDR
A role for Vinnexins in CsIV and more broadly Ichnovirus pathology in infected lepidopteran hosts, particularly in disrupting multicellular developmental and immune physiology is supported.

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TLDR
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