Intracellular domains of target antigens influence their capacity to trigger antibody-dependent cell-mediated cytotoxicity.

@article{Tiroch2002IntracellularDO,
  title={Intracellular domains of target antigens influence their capacity to trigger antibody-dependent cell-mediated cytotoxicity.},
  author={Klaus Tiroch and Bernhard Stockmeyer and Carola Frank and Thomas Valerius},
  journal={Journal of immunology},
  year={2002},
  volume={168 7},
  pages={3275-82}
}
Ab-mediated signaling in tumor cells and Ab-dependent cell-mediated cytotoxicity (ADCC) are both considered as relevant effector mechanisms for Abs in tumor therapy. To address potential interactions between these two mechanisms, we generated HER-2/neu- and CD19-derived chimeric target Ags, which were expressed in experimental tumor target cells. HER-2/neu… CONTINUE READING