Intracellular distribution of psychotropic drugs in the grey and white matter of the brain: the role of lysosomal trapping.

@article{Daniel2001IntracellularDO,
  title={Intracellular distribution of psychotropic drugs in the grey and white matter of the brain: the role of lysosomal trapping.},
  author={Władysława Anna Daniel and Jacek W{\'o}jcikowski and Agnieszka Pałucha},
  journal={British journal of pharmacology},
  year={2001},
  volume={134 4},
  pages={807-14}
}
1. Since the brain is not a homogenous organ (i.e. the phospholipid pattern and density of lysosomes may vary in its different regions), in the present study we examined the uptake of psychotropic drugs by vertically cut slices of whole brain, grey (cerebral cortex) and white (corpus callosum, internal capsule) matter of the brain and by neuronal and astroglial cell cultures. 2. Moreover, we assessed the contribution of lysosomal trapping to total drug uptake (total uptake=lysosomal trapping… CONTINUE READING
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