Intracellular distribution of oligonucleotides delivered by cationic liposomes: light and electron microscopic study.

@article{Lappalainen1997IntracellularDO,
  title={Intracellular distribution of oligonucleotides delivered by cationic liposomes: light and electron microscopic study.},
  author={Katriina Lappalainen and Riitta Miettinen and Jari Kellokoski and Ilpo J{\"a}{\"a}skel{\"a}inen and Stina M Syrj{\"a}nen},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={1997},
  volume={45 2},
  pages={265-74}
}
Synthesized oligonucleotides are used in anti-sense and anti-gene technology to control gene expression. Because cells do not easily take up oligonucleotides, cationic liposomes have been employed to facilitate their transport into cells. Although cationic liposomes have been used in this way for several years, the precise mechanisms of the delivery of oligonucleotides into cells are not known. Because no earlier reports have been published on the liposomal delivery of oligonucleotides at the… CONTINUE READING