Intracellular distribution of anthracyclines in drug resistant cells.

Abstract

The unresponsiveness of multidrug resistant tumor cells to antineoplastic chemotherapy is often associated with reduced cellular drug accumulation accomplished by overexpressed transport molecules. Moreover, intracellular drug distribution in resistant cells appears to be remarkably different when compared to their wild type counterparts. In the present… (More)
DOI: 10.1023/A:1008040117882

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