Intracellular delivery of core-shell fluorescent silica nanoparticles.

@article{Fuller2008IntracellularDO,
  title={Intracellular delivery of core-shell fluorescent silica nanoparticles.},
  author={Jason Fuller and Gregory T. Zugates and Lino Ferreira and Hooisweng S Ow and Nicholas Hoai Nam Nguyen and Ulrich B Wiesner and Robert S Langer},
  journal={Biomaterials},
  year={2008},
  volume={29 10},
  pages={1526-32}
}
Highly fluorescent core-shell silica nanoparticles made by the modified Stöber process (C dots) are promising as tools for sensing and imaging subcellular agents and structures but will only be useful if they can be easily delivered to the cytoplasm of the subject cells. This work shows that C dots can be electrostatically coated with cationic polymers, changing their surface charge and enabling them to escape from endosomes and enter the cytoplasm and nucleus. As an example of cellular… CONTINUE READING

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