Intracellular coupling modulates biflagellar synchrony

@article{Guo2021IntracellularCM,
  title={Intracellular coupling modulates biflagellar synchrony},
  author={Hanliang Guo and Yi Man and Kirsty Y. Wan and Eva Kanso},
  journal={Journal of the Royal Society Interface},
  year={2021},
  volume={18}
}
Beating flagella exhibit a variety of synchronization modes. This synchrony has long been attributed to hydrodynamic coupling between the flagella. However, recent work with flagellated algae indicates that a mechanism internal to the cell, through the contractile fibres connecting the flagella basal bodies, must be at play to actively modulate flagellar synchrony. Exactly how basal coupling mediates flagellar coordination remains unclear. Here, we examine the role of basal coupling in the… Expand
9 Citations

Figures and Tables from this paper

Multisynchrony in Active Microfilaments.
TLDR
This work uses an elastohydrodynamic filament model in conjunction with numerical simulations and a Floquet-type theoretical analysis to demonstrate that it is possible to reach multiple synchronization states by varying the intrinsic activity of the filament and the strength of hydrodynamic coupling between the two filaments. Expand
A minimal robophysical model of quadriflagellate self-propulsion
TLDR
This work developed autonomous, algae-inspired robophysical models that can self-propel in a viscous fluid and creates a minimal robot that can successfully reproduce cilia-inspired drag-based swimming, paving the way for the design of next-generation devices that have the capacity to autonomously navigate aqueous environments. Expand
A minimal robophysical model of quadriflagellate self-propulsion
Locomotion at the microscale is remarkably sophisticated. Microorganisms have evolved diverse strategies to move within highly viscous environments, using deformable, propulsion-generating appendagesExpand
Asymptotic theory of hydrodynamic interactions between slender filaments
Hydrodynamic interactions are important in biophysics because they influence the collective behaviour of microorganisms and active particles, and also play a key role in the emergence of swimmingExpand
Excitable mechanics embodied in a walking cilium
Rapid transduction of sensory stimulation to action is essential for an animal to survive. To this end, most animals use the sub-second excitable and multistable dynamics of a neuromuscular system.Expand
Metachronal motion across scales: current challenges and future directions.
TLDR
An overview of known commonalities and differences between systems that use metachrony to generate fluid flow is provided and strategies for standardizing terminology and defining future investigative directions are discussed. Expand
Multi-ciliated microswimmers–metachronal coordination and helical swimming
TLDR
The swimming velocity is found to increase with the cilia number N with a slightly sublinear power law, consistent with the behavior expected from the dependence of the transport velocity of planar cilia arrays on the cili separation. Expand
The Role of the Double-Layer Potential in Regularised Stokeslet Models of Self-Propulsion
The method of regularised stokeslets is widely used to model microscale biological propulsion. The method is usually implemented with only the single-layer potential, the double-layer potential beingExpand
The structure and function of centriolar rootlets
TLDR
It is suggested that the capability of rootlets to form physical links from centrioles to other cellular structures is a general principle unifying their functions in diverse cells and serves as an example of how cellular function arises from collective organellar activity. Expand

References

SHOWING 1-10 OF 57 REFERENCES
Coordinated beating of algal flagella is mediated by basal coupling
TLDR
The insufficiency of hydrodynamic coupling is demonstrated in an evolutionarily significant range of unicellular algal species bearing multiple flagella, and it is suggested that the key additional ingredient for precise coordination of flagellar beating is provided by contractile fibers of the basal apparatus. Expand
Flagellar synchronization through direct hydrodynamic interactions
TLDR
This study proves unequivocally that flagella coupled solely through a fluid can achieve robust synchrony despite differences in their intrinsic properties. Expand
Transitions in synchronization states of model cilia through basal-connection coupling
TLDR
This work focuses on the model biflagellate Chlamydomonas reinhardtii, and proposes a minimal model for the synchronization of its two flagella as a result of both hydrodynamic and direct mechanical coupling. Expand
Lag, lock, sync, slip: the many ‘phases’ of coupled flagella
TLDR
High-speed, high-resolution imaging of single pipette-held cells is used to quantify the rich dynamics exhibited by their flagella, and mechanically induced removal of one or the other flagellum of the same cell is revealed to reveal a striking disparity between the beatings of the cis and trans flageLLum, in isolation. Expand
In-phase and anti-phase flagellar synchronization by waveform compliance and basal coupling
TLDR
From a theory of flagellar synchronization in the green alga Chlamydomonas, quantitatively predict different synchronization dynamics in fluids of increased viscosity or external flow, suggesting a non-invasive way to control synchronization by hydrodynamic coupling. Expand
Bistability in the synchronization of actuated microfilaments
Cilia and flagella are essential building blocks for biological fluid transport and locomotion at the micrometre scale. They often beat in synchrony and may transition between differentExpand
Antiphase synchronization in a flagellar-dominance mutant of Chlamydomonas.
TLDR
The discovery is reported that ptx1, a flagellar-dominance mutant of C. reinhardtii, can exhibit synchronization in precise antiphase, as in the freestyle swimming stroke, and that the latter has a distinct waveform and significantly higher frequency. Expand
Hydrodynamics Versus Intracellular Coupling in the Synchronization of Eukaryotic Flagella.
TLDR
The results suggest that synchronization is due instead to coupling through cell internal fibers connecting the flagella, and this conclusion is confirmed by observations of the vfl3 mutant, with impaired mechanical connection between theFlagella. Expand
Multisynchrony in Active Microfilaments.
TLDR
This work uses an elastohydrodynamic filament model in conjunction with numerical simulations and a Floquet-type theoretical analysis to demonstrate that it is possible to reach multiple synchronization states by varying the intrinsic activity of the filament and the strength of hydrodynamic coupling between the two filaments. Expand
Flagellar coordination in Chlamydomonas cells held on micropipettes.
TLDR
Analysis of a great number of shock responses revealed that in undulatory beats also periods of bilateral coordination are found and that the coordination type may change several times during a shock response, without concomitant changes of the beat envelope and the beat period. Expand
...
1
2
3
4
5
...