Intracellular competition for fates in the immune system.

  title={Intracellular competition for fates in the immune system.},
  author={Ken R. Duffy and Philip D. Hodgkin},
  journal={Trends in cell biology},
  volume={22 9},
During an adaptive immune response, lymphocytes proliferate for five to 20 generations, differentiating to take on effector functions, before cessation and cell death become dominant. Recent experimental methodologies enable direct observation of individual lymphocytes and the times at which they adopt fates. Data from these experiments reveal diversity in fate selection, heterogeneity and involved correlation structures in times to fate, as well as considerable familial correlations. Despite… CONTINUE READING
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