Intracellular class II HLA antigens are accessible to transferrin-neuraminidase conjugates internalized by receptor-mediated endocytosis.

@article{Cresswell1985IntracellularCI,
  title={Intracellular class II HLA antigens are accessible to transferrin-neuraminidase conjugates internalized by receptor-mediated endocytosis.},
  author={Peter Cresswell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1985},
  volume={82 23},
  pages={
          8188-92
        }
}
Newly synthesized class II HLA antigens being transported to the surface of human B-lymphoblastoid cell lines (B-LCL) interact with transferrin-neuraminidase conjugates internalized by means of receptor-mediated endocytosis. Class II antigens, isolated from [35S]methionine-labeled B-LCL after incubation with the conjugates at 37 degrees C, showed extensive desialylation of associated invariant chain and detectable loss of beta-subunit sialic acid on analysis by two-dimensional gel… CONTINUE READING

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