Intracellular cholesterol transporter StarD4 binds free cholesterol and increases cholesteryl ester formation.

@article{RodrguezAgudo2008IntracellularCT,
  title={Intracellular cholesterol transporter StarD4 binds free cholesterol and increases cholesteryl ester formation.},
  author={Daniel Rodr{\'i}guez-Agudo and Shunlin Ren and Eric T. T. Wong and Dalila Marques and Kaye Redford and Gregorio Gil and Phillip B. Hylemon and William M. Pandak},
  journal={Journal of lipid research},
  year={2008},
  volume={49 7},
  pages={1409-19}
}
StarD4 protein is a member of the StarD4 subfamily of steroidogenic acute regulatory-related lipid transfer (START) domain proteins that includes StarD5 and StarD6, proteins whose functions remain poorly defined. The objective of this study was to isolate and characterize StarD4's sterol binding and to determine in a hepatocyte culture model its sterol transport capabilities. Utilizing purified full-length StarD4, in vitro binding assays demonstrated a concentration-dependent binding of [(14)C… CONTINUE READING

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The liver: biology and pathobiology

  • P. B. Hylemon, W. M. Pandak, Z. R. Vlahcevic
  • In The Liver
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Highly Influential
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