Intracellular cholesterol homeostasis and amyloid precursor protein processing.

@article{Burns2010IntracellularCH,
  title={Intracellular cholesterol homeostasis and amyloid precursor protein processing.},
  author={Mark P Burns and G William Rebeck},
  journal={Biochimica et biophysica acta},
  year={2010},
  volume={1801 8},
  pages={
          853-9
        }
}
Many preclinical and clinical studies have implied a role for cholesterol in the pathogenesis of Alzheimer's disease (AD). In this review we will discuss the movement of intracellular cholesterol and how normal distribution, transport, and export of cholesterol are vital for regulation of the AD related protein, Abeta. We focus on cholesterol distribution in the plasma membrane, transport through the endosomal/lysosomal system, control of cholesterol intracellular signaling at the endoplasmic… CONTINUE READING
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