Intracellular chloride channel protein CLIC1 regulates macrophage function through modulation of phagosomal acidification.

@article{Jiang2012IntracellularCC,
  title={Intracellular chloride channel protein CLIC1 regulates macrophage function through modulation of phagosomal acidification.},
  author={Lele Jiang and Kanin Salao and Hui Li and Joanna M Rybicka and Robin M Yates and Xu Wei Luo and Xin Xin Shi and Tamara Kuffner and Vicky Wang-Wei Tsai and Yasmin Husaini and Liyun Wu and David Adam Brown and Thomas Grewal and Louise Jennifer Brown and Paul M. G. Curmi and Samuel N Breit},
  journal={Journal of cell science},
  year={2012},
  volume={125 Pt 22},
  pages={5479-88}
}
Intracellular chloride channel protein 1 (CLIC1) is a 241 amino acid protein of the glutathione S transferase fold family with redox- and pH-dependent membrane association and chloride ion channel activity. Whilst CLIC proteins are evolutionarily conserved in Metazoa, indicating an important role, little is known about their biology. CLIC1 was first cloned on the basis of increased expression in activated macrophages. We therefore examined its subcellular localisation in murine peritoneal… CONTINUE READING
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