Intracellular cations modulate noradrenaline-stimulated calcium entry into smooth muscle cells of rat portal vein.

@article{Pacaud1992IntracellularCM,
  title={Intracellular cations modulate noradrenaline-stimulated calcium entry into smooth muscle cells of rat portal vein.},
  author={Pierre Pacaud and Gervaise Loirand and Thomas B. Bolton and Chantal Mironneau and Jean Mironneau},
  journal={The Journal of physiology},
  year={1992},
  volume={456},
  pages={541-56}
}
1. The action of noradrenaline (NA, 10 microM) was studied in single patch-clamped smooth muscle cells of rat portal vein where free internal Ca2+ concentration in the cell (Ca2+i) was estimated using the emission from the dye Indo-1. 2. In the presence of 50 microM D600, a blocker of voltage-dependent Ca2+ channels, NA applied to the cell evoked an initial peak in Ca2+i followed by a smaller sustained rise. The initial rise in Ca2+i was associated with the activation of Ca(2+)-dependent Cl… CONTINUE READING
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