Intracellular calcium regulates the survival of early sensory neurons before they become dependent on neurotrophic factors.

@article{Larmet1992IntracellularCR,
  title={Intracellular calcium regulates the survival of early sensory neurons before they become dependent on neurotrophic factors.},
  author={Y Larmet and Annette C Dolphin and Alun M Davies},
  journal={Neuron},
  year={1992},
  volume={9 3},
  pages={563-74}
}
To investigate the role of intracellular Ca2+ in the survival of developing neurons before they become neurotrophic factor dependent, we have studied chick embryo nodose neurons, which have a particularly protracted period of neuorophic factor independence. Pharmacological reduction of intracellular free Ca2+ or depletion of either Ca(2+)-regulated or inositol trisphosphate-regulated intracellular Ca2+ stores kills early neurotrophic factor-independent neurons, but has a negligible effect on… CONTINUE READING

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