Intracellular calcium mobilization and neurite outgrowth in mammalian neurons.

@article{Kocsis1994IntracellularCM,
  title={Intracellular calcium mobilization and neurite outgrowth in mammalian neurons.},
  author={Jeffery D Kocsis and Mark N. Rand and Karen L. Lankford and Stephen G. Waxman},
  journal={Journal of neurobiology},
  year={1994},
  volume={25 3},
  pages={
          252-64
        }
}
Cultured adult rat dorsal root ganglion (DRG) neurons were used to study depolarization-induced Ca2+ mobilization and the effects of intracellular Ca2+ depletion on neurite outgrowth. Cytoplasmic and nuclear Ca2+ signals were visualized in dissociated DRG neurons using confocal scanning laser microscopy and the Ca2+ indicator dye fluo-3. The depolarization-induced Ca2+ signals were highest in neurons during the first few days in culture, prior to neurite extension; during this time nuclear… CONTINUE READING

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