Intracellular calcium channels: inositol-1,4,5-trisphosphate receptors.

@article{Fedorenko2014IntracellularCC,
  title={Intracellular calcium channels: inositol-1,4,5-trisphosphate receptors.},
  author={Olena A. Fedorenko and Elena A Popugaeva and Masahiro Enomoto and Peter B Stathopulos and Mitsuhiko Ikura and Ilya B Bezprozvanny},
  journal={European journal of pharmacology},
  year={2014},
  volume={739},
  pages={
          39-48
        }
}
The inositol-1,4,5-trisphosphate receptors (InsP3Rs) are the major intracellular Ca(2+)-release channels in cells. Activity of InsP3Rs is essential for elementary and global Ca(2+) events in the cell. There are three InsP3Rs isoforms that are present in mammalian cells. In this review we will focus primarily on InsP3R type 1. The InsP3R1 is a predominant isoform in neurons and it is the most extensively studied isoform. Combination of biophysical and structural methods revealed key mechanisms… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 154 REFERENCES

CaBP1, a neuronal Ca2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2013
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2009
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Inositol trisphosphate and calcium signalling mechanisms.

  • Biochimica et biophysica acta
  • 2009
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2008
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

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