Intracellular calcium channels: inositol-1,4,5-trisphosphate receptors.

@article{Fedorenko2014IntracellularCC,
  title={Intracellular calcium channels: inositol-1,4,5-trisphosphate receptors.},
  author={Olena A. Fedorenko and Elena A Popugaeva and Masahiro Enomoto and Peter B Stathopulos and Mitsuhiko Ikura and Ilya B Bezprozvanny},
  journal={European journal of pharmacology},
  year={2014},
  volume={739},
  pages={
          39-48
        }
}
The inositol-1,4,5-trisphosphate receptors (InsP3Rs) are the major intracellular Ca(2+)-release channels in cells. Activity of InsP3Rs is essential for elementary and global Ca(2+) events in the cell. There are three InsP3Rs isoforms that are present in mammalian cells. In this review we will focus primarily on InsP3R type 1. The InsP3R1 is a predominant isoform in neurons and it is the most extensively studied isoform. Combination of biophysical and structural methods revealed key mechanisms… CONTINUE READING
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