Intracellular calcium and the mechanism of anodal supernormal excitability in langendorff perfused rabbit ventricles.

@article{Joung2011IntracellularCA,
  title={Intracellular calcium and the mechanism of anodal supernormal excitability in langendorff perfused rabbit ventricles.},
  author={Boyoung Joung and H J Park and Mitsunori Maruyama and Liang Tang and Juan Song and Seongwook Han and Gianfranco Piccirillo and James N. Weiss and Shien-Fong Lin and Peng-Sheng Chen},
  journal={Circulation journal : official journal of the Japanese Circulation Society},
  year={2011},
  volume={75 4},
  pages={834-43}
}
BACKGROUND Anodal stimulation hyperpolarizes the cell membrane and increases the intracellular Ca(2+) (Ca(i)) transient. This study tested the hypothesis that the maximum slope of the Ca(i) decline (-(dCa(i)/dt)(max)) corresponds to the timing of anodal dip on the strength-interval curve and the initiation of repetitive responses and ventricular fibrillation (VF) after a premature stimulus (S(2)). METHODS AND RESULTS We simultaneously mapped the membrane potential (V(m)) and Ca(i) in 23… CONTINUE READING

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