Intracellular beta-tubulin/chaperonin containing TCP1-beta complex serves as a novel chemotherapeutic target against drug-resistant tumors.

Abstract

In the present study, treatment of HEK-293 cells with the synthetic small molecule N-iodoacetyl-tryptophan (I-Trp) at submicromolar concentrations efficiently induced cell apoptosis as judged from the accumulation of sub-G(0) cells and intracellular DNA fragmentation. Activation of all intracellular caspases, except caspase-1, was detected in I-Trp-treated… (More)
DOI: 10.1158/0008-5472.CAN-08-4700

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@article{Lin2009IntracellularBC, title={Intracellular beta-tubulin/chaperonin containing TCP1-beta complex serves as a novel chemotherapeutic target against drug-resistant tumors.}, author={Yuan-Feng Lin and Wen-Ping Tsai and Hon-Ge Liu and Po-Huang Liang}, journal={Cancer research}, year={2009}, volume={69 17}, pages={6879-88} }