Intracellular application of TNF-alpha impairs cell to cell communication via gap junctions in glioma cells

@article{Haghikia2007IntracellularAO,
  title={Intracellular application of TNF-alpha impairs cell to cell communication via gap junctions in glioma cells},
  author={Aiden Haghikia and Kerstin Ladage and Pauline Laf{\^e}netre and Arash Haghikia and Daniel Hinkerohe and Dirk Smikalla and Claus Gert Haase and Rolf Dermietzel and Pedro M. Faustmann},
  journal={Journal of Neuro-Oncology},
  year={2007},
  volume={86},
  pages={143-152}
}
Human gliomas are the most common class of brain neoplasm. In order to better characterize their response to inflammation, we evaluated the influence of tumor necrosis factor alpha (TNF-α) on the coupling behaviour and the membrane resting potential (MRP) of glioma cells (F98 glioma cell line) compared to primary astrocytes. In contrast to cultured primary astrocytes which exhibited a profound inhibition of gap junction mediated intercellular communication (GJIC), extracellular exposure of TNF… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 56 references

Similar Papers

Loading similar papers…