Intracellular and interstitial expression of Helicobacter pylori virulence genes in gastric precancerous intestinal metaplasia and adenocarcinoma.

@article{SeminoMora2003IntracellularAI,
  title={Intracellular and interstitial expression of Helicobacter pylori virulence genes in gastric precancerous intestinal metaplasia and adenocarcinoma.},
  author={Cristina Semino-Mora and Sonia de Quateli Doi and Aileen M. Marty and Vlado Simko and Ingemar Carlstedt and Andr{\'e} DuBois},
  journal={The Journal of infectious diseases},
  year={2003},
  volume={187 8},
  pages={1165-77}
}
Gastric intestinal metaplasia (IM) and gastric cancer are associated with Helicobacter pylori, but the bacterium often is undetectable in these lesions. To unravel this apparent paradox, IM, H. pylori presence, and the expression of H. pylori virulence genes were quantified concurrently using histologic testing, in situ hybridization, and immunohistochemistry. H. pylori was detected inside metaplastic, dysplastic, and neoplastic epithelial cells, and cagA and babA2 expression was colocalized… CONTINUE READING