Intracellular and extracellular loops of LRRC8 are essential for volume-regulated anion channel function

  title={Intracellular and extracellular loops of LRRC8 are essential for volume-regulated anion channel function},
  author={Toshiki Yamada and K. Strange},
  journal={The Journal of General Physiology},
  pages={1003 - 1015}
The volume-regulated anion channel (VRAC) is expressed ubiquitously in vertebrate cells and mediates swelling-induced release of Cl− and organic solutes. Recent studies by several laboratories have demonstrated conclusively that VRAC is encoded by members of the leucine-rich repeat containing 8 (Lrrc8) gene family, which comprises five members, termed Lrrc8a–e. Numerous observations indicate that VRAC is a heteromeric channel comprising the essential subunit LRRC8A and one or more of the other… Expand
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