Intracellular and cell-to-cell spread of Listeria monocytogenes involves interaction with F-actin in the enterocytelike cell line Caco-2.

@article{Mounier1990IntracellularAC,
  title={Intracellular and cell-to-cell spread of Listeria monocytogenes involves interaction with F-actin in the enterocytelike cell line Caco-2.},
  author={Jo{\"e}lle Mounier and Antoinette Ryter and M Coquis-Rondon and Philippe J Sansonetti},
  journal={Infection and immunity},
  year={1990},
  volume={58 4},
  pages={1048-58}
}
Listeria monocytogenes penetrates and multiplies within professional phagocytes and other cells such as the Caco-2 human enterocytelike cell line. Listeriolysin O, a membrane-damaging cytotoxin accounts for intracellular multiplication through lysis of the membrane-bound phagocytic vacuole. This work demonstrates that once released within the cytosol, L. monocytogenes acquires the capacity to spread intracellularly and infect adjacent cells by interacting with host cell microfilaments. Such… CONTINUE READING

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