Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: study of antibiotic combinations.

@article{Nguyen2009IntracellularAO,
  title={Intracellular activity of antibiotics in a model of human THP-1 macrophages infected by a Staphylococcus aureus small-colony variant strain isolated from a cystic fibrosis patient: study of antibiotic combinations.},
  author={Hoang Anh B. Nguyen and Olivier Denis and Anne Vergison and Paul M Tulkens and Marc Jean Struelens and Françoise Van Bambeke},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 4},
  pages={
          1443-9
        }
}
In a companion paper (H. A. Nguyen et al., Antimicrob. Agents Chemother. 53:1434-1442, 2009), we showed that vancomycin, oxacillin, fusidic acid, clindamycin, linezolid, and daptomycin are poorly active against the intracellular form of a thymidine-dependent small-colony variant (SCV) strain isolated from a cystic fibrosis patient and that the activity of quinupristin-dalfopristin, moxifloxacin, rifampin, and oritavancin remains limited (2- to 3-log CFU reduction) compared to their… CONTINUE READING

Citations

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Small colony variants (SCVs) of Staphylococcus aureus--a bacterial survival strategy.

  • Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
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Oritavancin: an investigational lipoglycopeptide antibiotic.

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