Intracellular activation of albomycin in Escherichia coli and Salmonella typhimurium.

@article{Braun1983IntracellularAO,
  title={Intracellular activation of albomycin in Escherichia coli and Salmonella typhimurium.},
  author={Volkmar Braun and K G{\"u}nthner and Klaus Hantke and Luitgart Zimmermann},
  journal={Journal of bacteriology},
  year={1983},
  volume={156 1},
  pages={308-15}
}
The antibiotic albomycin is actively taken up by Escherichia coli via the transport system for the structurally similar iron complex ferrichrome. Albomycin is cleaved, and the antibiotically active moiety is released into the cytoplasm, whereas the iron carrier moiety appears in the medium. Besides transport-negative mutants, additional albomycin-resistant mutants were isolated. The mutations were mapped outside the transport genes close to the pyrD gene at 21 min. The mutants were devoid of… CONTINUE READING