Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1

@article{Kleemann2000IntracellularAO,
  title={Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1},
  author={R. Kleemann and A. Hausser and Georg Geiger and R. Mischke and A. Burger-Kentischer and O. Flieger and F. Johannes and T. Roger and T. Calandra and A. Kapurniotu and M. Grell and Doris Finkelmeier and H. Brunner and J. Bernhagen},
  journal={Nature},
  year={2000},
  volume={408},
  pages={211-216}
}
Cytokines are multifunctional mediators that classically modulate immune activity by receptor-mediated pathways. Macrophage migration inhibitory factor (MIF) is a cytokine that has a critical role in several inflammatory conditions but that also has endocrine and enzymatic functions. The molecular targets of MIF action have so far remained unclear. Here we show that MIF specifically interacts with an intracellular protein, Jab1, which is a coactivator of AP-1 transcription that also promotes… Expand
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