Intracellular accumulation of aggregated pyroglutamate amyloid beta: convergence of aging and Aβ pathology at the lysosome

@inproceedings{Kimpe2012IntracellularAO,
  title={Intracellular accumulation of aggregated pyroglutamate amyloid beta: convergence of aging and Aβ pathology at the lysosome},
  author={Line De Kimpe and Elise S. van Haastert and Archontia Kaminari and Rob Zwart and Helma Rutjes and Jeroen J. M. Hoozemans and Wiep Scheper},
  booktitle={AGE},
  year={2012}
}
Deposition of aggregated amyloid beta (Aβ) is a major hallmark of Alzheimer’s disease (AD)—a common age-related neurodegenerative disorder. Typically, Aβ is generated as a peptide of varying lengths. However, a major fraction of Aβ peptides in the brains of AD patients has undergone posttranslational modifications, which often radically change the properties of the peptides. Aβ3(pE)-42 is an N-truncated, pyroglutamate-modified variant that is abundantly present in AD brain and was suggested to… CONTINUE READING
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