Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein.

@article{Knauer1992IntracellularAA,
  title={Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein.},
  author={Mary F Knauer and Brian Soreghan and Deborah A. Burdick and Joseph V Kosmoski and Charles G. Glabe},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 16},
  pages={7437-41}
}
The A4 or beta protein is a peptide that constitutes the major protein component of senile plaques in Alzheimer disease. The A4/beta protein is derived from a larger, transmembrane amyloid precursor protein (APP). The putative abnormal processing events leading to amyloid accumulation are largely unknown. Here we report that a 42-residue synthetic peptide, beta 1-42, corresponding to one of the longer forms of the A4/beta protein, accumulates in cultured human skin fibroblasts and is stable for… CONTINUE READING

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