Intracellular Trafficking of Interleukin-1 Receptor I Requires Tollip

  title={Intracellular Trafficking of Interleukin-1 Receptor I Requires Tollip},
  author={Brian Brissoni and Laetitia Agostini and Michel Kropf and Fabio Martinon and Valentin Swoboda and Saskia Lippens and Helen Everett and Natalia Aebi and Sophie Janssens and Etienne Meylan and Michela Felberbaum-Corti and Harald Hirling and Jean Gruenberg and J. -M. Tschopp and Kimberly Burns},
  journal={Current Biology},
Interleukin-1 receptor (IL-1RI) is a master regulator of inflammation and innate immunity. When triggered by IL-1beta, IL-1RI aggregates with IL-1R-associated protein (IL-1RAcP) and forms a membrane proximal signalosome that potently activates downstream signaling cascades. IL-1beta also rapidly triggers endocytosis of IL-1RI. Although internalization of IL-1RI significantly impacts signaling, very little is known about trafficking of IL-1RI and therefore about precisely how endocytosis… CONTINUE READING
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