Intracellular TRPA1 mediates Ca2+ release from lysosomes in dorsal root ganglion neurons

  title={Intracellular TRPA1 mediates Ca2+ release from lysosomes in dorsal root ganglion neurons},
  author={Shujiang Shang and Feipeng Zhu and Bin Liu and Zuying Chai and Qihui Wu and Meiqin Hu and Yuan Wang and Rong Huang and Xiaoyu Zhang and Xi Wu and Lei Sun and Yeshi Wang and Liang Wang and Huadong Xu and Sasa Teng and Bing Liu and Lianghong Zheng and Chen Zhang and Fukang Zhang and Xinghua Feng and Desheng Zhu and Changhe Wang and Tao Liu and Michael Xi Zhu and Zhuan Zhou},
  booktitle={The Journal of cell biology},
Transient receptor potential A1 (TRPA1) is a nonselective cation channel implicated in thermosensation and inflammatory pain. In this study, we show that TRPA1 (activated by allyl isothiocyanate, acrolein, and 4-hydroxynonenal) elevates the intracellular Ca2+ concentration ([Ca2+]i) in dorsal root ganglion (DRG) neurons in the presence and absence of extracellular Ca2+ Pharmacological and immunocytochemical analyses revealed the presence of TRPA1 channels both on the plasma membrane and in… CONTINUE READING
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ANK TM 1 , a TRP - like channel expressed in nociceptive neurons , is activated by cold temperatures

  • G. M. Story, M. A., +4 authors S. W. Hwang D. A. Andersson
  • 2003
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