Intracellular Salmonella induces aggrephagy of host endomembranes in persistent infections.

@article{LpezMontero2016IntracellularSI,
  title={Intracellular Salmonella induces aggrephagy of host endomembranes in persistent infections.},
  author={Noelia L{\'o}pez-Montero and Estel Ramos-Marqu{\`e}s and Cristina M Risco and Francisco Garc{\'i}a-Del Portillo},
  journal={Autophagy},
  year={2016},
  volume={12 10},
  pages={
          1886-1901
        }
}
Xenophagy has been studied in epithelial cells infected with Salmonella enterica serovar Typhimurium (S. Typhimurium). Distinct autophagy receptors target this pathogen to degradation after interacting with ubiquitin on the surface of cytosolic bacteria, and the phagophore- and autophagosome-associated protein MAP1LC3/LC3. Glycans exposed in damaged phagosomal membranes and diacylglycerol accumulation in the phagosomal membrane also trigger S. Typhimurium xenophagy. How these responses control… CONTINUE READING
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