Intracellular Proton Regulation of ClC-0

@article{Zifarelli2008IntracellularPR,
  title={Intracellular Proton Regulation of ClC-0},
  author={Giovanni Zifarelli and Anna Rosa Murgia and Paolo Soliani and Michael Pusch},
  journal={The Journal of General Physiology},
  year={2008},
  volume={132},
  pages={185 - 198}
}
Some CLC proteins function as passive Cl(-) ion channels whereas others are secondary active chloride/proton antiporters. Voltage-dependent gating of the model Torpedo channel ClC-0 is modulated by intracellular and extracellular pH, possibly reflecting a mechanistic relationship with the chloride/proton coupling of CLC antiporters. We used inside-out patch clamp measurements and mutagenesis to explore the dependence of the fast gating mechanism of ClC-0 on intracellular pH and to identify the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Roles of K 149 , G 352 , and H 401 in the channel functions of ClC - 0 : testing the predictions from theoretical calculations

  • Y. Li, W. P. Yu, T. Y. Chen
  • J . Gen . Physiol .
  • 2006

Similar Papers

Loading similar papers…