Intracellular Ph Regulation by Na+/H+ Exchange Requires Phosphatidylinositol 4,5-Bisphosphate

@article{Aharonovitz2000IntracellularPR,
  title={Intracellular Ph Regulation by Na+/H+ Exchange Requires Phosphatidylinositol 4,5-Bisphosphate},
  author={Orit Aharonovitz and Hans C. Zaun and Tamas Balla and John D. York and John Orlowski and Sergio Grinstein},
  journal={The Journal of Cell Biology},
  year={2000},
  volume={150},
  pages={213 - 224}
}
The carrier-mediated, electroneutral exchange of Na(+) for H(+) across the plasma membrane does not directly consume metabolic energy. Nevertheless, acute depletion of cellular ATP markedly decreases transport. We analyzed the possible involvement of polyphosphoinositides in the metabolic regulation of NHE1, the ubiquitous isoform of the Na(+)/H(+) exchanger. Depletion of ATP was accompanied by a marked reduction of plasmalemmal phosphatidylinositol 4,5-bisphosphate (PIP(2)) content. Moreover… CONTINUE READING

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