Intracellular Parasite Invasion Strategies

  title={Intracellular Parasite Invasion Strategies},
  author={L. David Sibley},
  pages={248 - 253}
  • L. Sibley
  • Published 9 April 2004
  • Biology
  • Science
Intracellular parasites use various strategies to invade cells and to subvert cellular signaling pathways and, thus, to gain a foothold against host defenses. Efficient cell entry, ability to exploit intracellular niches, and persistence make these parasites treacherous pathogens. Most intracellular parasites gain entry via host-mediated processes, but apicomplexans use a system of adhesion-based motility called “gliding” to actively penetrate host cells. Actin polymerization–dependent motility… 

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Recent findings collected in Plasmodium sporozoites and related parasites are highlighted and discussed that shed new light on the biological significance of apicomplexan motility and on the structure and regulation of the underlying motor machinery.



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