Intracellular Localization and Functional Effects of P 21-Activated Kinase-1 ( Pak 1 ) in Cardiac Myocytes

@inproceedings{Ke2003IntracellularLA,
  title={Intracellular Localization and Functional Effects of P 21-Activated Kinase-1 ( Pak 1 ) in Cardiac Myocytes},
  author={Yunbo Ke and Lynn H Wang and William Glen Pyle and Pieter de P. Tombe and Ross J. Solaro},
  year={2003}
}
We investigated intracellular localization and substrate specificity of P-activated kinase-1 (Pak1) in rat cardiac myocytes. Pak1 is a serine/threonine protein kinase that is activated by Rac1/Cdc42 and important in signaling of stress responses. Yet the localization and in vivo function of Pak1 in heart cells is poorly understood. Studies reported here indicate that Pak1 physically interacts with protein phosphatase 2a and localizes to the Z-disk, cell membrane, intercalated disc, and nuclear… CONTINUE READING

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