Intracellular Iron-Binding Macromolecules in HeLa Cells ( chelation / polysaccharide / protein / DNA synthesis / desferrioxamine )

Abstract

The concentration of the iron-chelating agent, desferrioxamine (Desferal), that just inhibits iron entry into HeLa cells is also the concentration that inhibits DNA synthesis. As a first step in clarification of the mechanism whereby iron may partake in DNA synthesis, we have partially characterized several of the intracellular iron-binding sites. Most… (More)

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