Intracellular Iron-Binding Macromolecules in HeLa Cells ( chelation / polysaccharide / protein / DNA synthesis / desferrioxamine )


The concentration of the iron-chelating agent, desferrioxamine (Desferal), that just inhibits iron entry into HeLa cells is also the concentration that inhibits DNA synthesis. As a first step in clarification of the mechanism whereby iron may partake in DNA synthesis, we have partially characterized several of the intracellular iron-binding sites. Most… (More)

9 Figures and Tables


  • Presentations referencing similar topics