Intracellular IFN-γ and IL-2 expression monitoring as surrogate markers of the risk of acute rejection and personal drug response in de novo liver transplant recipients.

@article{Milln2013IntracellularIA,
  title={Intracellular IFN-γ and IL-2 expression monitoring as surrogate markers of the risk of acute rejection and personal drug response in de novo liver transplant recipients.},
  author={Olga Mill{\'a}n and Lourdes Rafael-Valdivia and E Torradem{\'e} and Anna L{\'o}pez and Virginia Fortuna and Santiago S{\'a}nchez-Cab{\'u}s and Yolanda L{\'o}pez-P{\'u}a and Antoni Rimola and Merçe Brunet},
  journal={Cytokine},
  year={2013},
  volume={61 2},
  pages={556-64}
}
Biomarker monitoring is needed in transplantation to reflect individual response to immunosuppressive drugs and graft outcome. We evaluated intracellular expression and soluble production of interferon-(IFN)-γ and interleukin-(IL)-2 as predictive biomarkers of acute rejection (AR) and personal drug response. Pharmacokinetic-pharmacodynamic profiles were determined in 47 de novo liver recipients treated with tacrolimus, mycophenolate mofetil and prednisone. Of the 47 patients, AR occurred in… CONTINUE READING

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