Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice.

@article{Kang2014IntracellularHI,
  title={Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice.},
  author={Rui Kang and Qiuhong Zhang and Wen Hou and Zhenwen Yan and Ruochan Chen and Jillian Bonaroti and Preeti Bansal and Timothy R Billiar and Allan Tsung and Qingde Wang and David L. Bartlett and David Clement Whitcomb and Eugene B Chang and Xiaorong Zhu and Haichao Wang and Ben Lu and Kevin J Tracey and Lizhi Cao and Xue-gong Fan and Michael T Lotze and Herbert J. Iii Zeh and Daolin Tang},
  journal={Gastroenterology},
  year={2014},
  volume={146 4},
  pages={
          1097-107
        }
}
BACKGROUND & AIMS High mobility group box 1 (HMGB1) is an abundant protein that regulates chromosome architecture and also functions as a damage-associated molecular pattern molecule. Little is known about its intracellular roles in response to tissue injury or during subsequent local and systemic inflammatory responses. We investigated the function of Hmgb1 in mice after induction of acute pancreatitis. METHODS We utilized a Cre/LoxP system to create mice with pancreas-specific disruption in… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 66 CITATIONS, ESTIMATED 51% COVERAGE

Novel chemokine-like activities of histones in tumor metastasis

  • Oncotarget
  • 2016
VIEW 4 EXCERPTS
CITES METHODS & BACKGROUND

FILTER CITATIONS BY YEAR

2014
2019

CITATION STATISTICS

  • 2 Highly Influenced Citations

  • Averaged 9 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 50 REFERENCES

Deletion of IkappaBalpha Activates RelA to Reduce Acute Pancreatitis in Mice Through Up-regulation of Spi2A. Gastroenterology

P Neuhofer, S Liang, H Einwachter
  • 2012